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NWU

Town:

Potchefstroom

Position:

Postdoctoral Researcher

Experience Needed:

We are seeking a highly motivated post-doctoral researcher to join our team studying mitochondrial diseases. This exciting opportunity will involve using iPSC models to investigate the cellular consequences of complex I deficiency. The successful candidate will differentiate iPSCs into various cell types and utilise a range of cutting-edge techniques, including bioenergetics assays (O2k-FluoRespirometer, Seahorse XF Analyser), multi-platform metabolomics (LC/GC-MS, NMR), and immunofluorescent microscopy. In addition, the successful candidate will play a key role in using these iPSC models to develop novel treatment options for mitochondrial disease. This position offers a unique opportunity to make meaningful contributions to both disease understanding and the development of future therapies.

Requirements:

Core Requirements: • PhD in Biochemistry or related field obtained in the last 5 years. • Experience in iPSC culturing and differentiation. • Expertise in bioenergetics, metabolomics, and/or microscopy is desirable. • Interest in drug screening and therapeutic development is a plus. • Strong publication record. • Must be able to work independently and in a team.

Duties Include:

Responsibilities: • Culturing of iPSC lines and differentiation into various relevant cell types to model mitochondrial dysfunction. • Operate and troubleshoot specialised equipment (GC/LC-MS, O2k-FluoRespirometer, Seahorse XF Analyser); recognise and implement quality control measures where needed. • Prepare samples, develop assays, analyse data, report results and modify/adapt methodologies as required. • Prepare research proposals, reports and manuscripts; develop and deliver oral presentations at one or more conferences. • Write and publish papers using existing as well as own data. • Contribute to efficient operation of the laboratory working environment by carrying out general lab duties, such as replenishing common solutions or supplies, tidying common areas, or maintaining common equipment. • As part of the candidate’s professional development, supervision of postgraduate students and contribution to undergraduate classes (maximum of 20%) will be required. Scholarship: A competitive scholarship is available to the post-doctoral fellow for 1 to 3 years renewed annually, conditional on satisfactory academic progress. • The grant will fund the successful candidate at R249 600 per annum, non-taxable. This will be topped up with an additional R40 000 per annum. • A further amount of R20 000 per annum will be made available for research–related running costs. • A once-off amount to a maximum of R20 000 will be made available for relocation costs. • You will be required to purchase private medical cover unless you can show evidence of suitable existing cover. • Assistance in this regard can be provided by the international office.

Additional Info:

Application Requirements: • Suitable candidates are required to submit the following: • A letter of interest/introduction (max 1 page) in which the candidate motivates why they are suitable for this position. • A CV including details of conferences presentations and all publications. • The names and email addresses of at least three academics who have agreed to stand as referees on behalf of the applicant. • Certified copies of academic transcripts (these can be sent later, if the candidate’s application is successful). Email applications to: Prof Roan Louw (Roan.Louw@nwu.ac.za) Director: BioMMet North-West University, South Africa Closing date: 18 March 2025

Starting Date:

March 19, 2025

Date Created:

March 12, 2025

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